Iron metabolism

While iron is an essential cofactor for many proteins, its chemical properties also promote side reactions that damage macromolecules. Cellular iron concentration is thus strictly controlled. In previous studies, we have revealed a physiological mechanism involving proteolytic control of iron metabolism by FBXL5, an iron sensor in a SCF ubiquitin ligase complex. FBXL5 ensures proper iron supply to cells and is pivotal for embryogenesis, stem cell maintenance, differentiation, and tissue homeostasis. Work in our lab is currently focusing on describing a new regulatory network controlling iron metabolism and understanding its role in immune regulation.

熊本大学 大学院生命科学研究部

総合医薬科学部門 代謝・循環医学分野



〒860-8556 熊本市中央区本荘1-1-1

(受付) TEL: 096-373-5173

FAX: 096-373-5313

E-MAIL: moroishi [at]

Department of Molecular and Medical Pharmacology

Faculty of Life Sciences, Kumamoto University


1-1-1 Honjo, Chuo-ku, Kumamoto,

Kumamoto 860-8556, JAPAN

(Desk) TEL: +81-96-373-5173

FAX: +81-96-373-5313
E-MAIL: moroishi [at]