Poorly immunogenic cancer cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been understood.
We recently discovered an unexpected and exciting role of the Hippo intracellular pathway in suppressing immunogenicity. Inhibition of the Hippo pathway in cancer cells leads to tumor destruction
by enhancing anti-cancer immunity via a mechanism involving extracellular vesicles.