The three keywords for our research are metabolism, cancer, and immunity. We previously revealed 1) an ubiquitin network involving the regulation of mammalian iron metabolism [Cell Metab. (2011)], 2) regulatory mechanisms of the Hippo intracellular pathway [Genes Dev. (2015)], and 3) involvement of extracellular vesicles in the induction of host anti-cancer immunity [Cell (2016)]. The goal of our research is to understand molecular mechanisms regulating tissue homeostasis, and to provide scientific basis for drug discovery.