The three keywords for our research are metabolism, cancer, and immunity. We previously revealed 1) an ubiquitin network involving the regulation of mammalian iron metabolism [Cell Metab. (2011)], 2) regulatory mechanisms of the Hippo intracellular
pathway [Genes Dev. (2015)], and 3) involvement of extracellular vesicles
in the induction of host anti-cancer immunity [Cell (2016)]. The
goal of our research is to understand molecular mechanisms regulating tissue homeostasis, and to provide scientific basis for drug discovery.
Work in our lab is currently focusing on describing a new regulatory network controlling iron metabolism.