The three keywords for our research are metabolism, cancer, and immunity. We previously revealed 1) an ubiquitin network involving the regulation of mammalian iron metabolism [Cell Metab. (2011)], 2) regulatory mechanisms of the Hippo intracellular
pathway [Genes Dev. (2015)], and 3) involvement of extracellular vesicles
in the induction of host anti-cancer immunity [Cell (2016)]. The
goal of our research is to understand molecular mechanisms regulating tissue homeostasis, and to provide scientific basis for drug discovery.
We recently discovered an unexpected and exciting role of the Hippo intracellular pathway in suppressing immunogenicity.