We aim to understand cellular communication in multicellular organisms, especially in the context of tumor microenvironment and/or tissue pathophysiology. The communication can be competitive or cooperative way.

The three keywords for our research are cancer, immunity, and iron metabolism. We previously revealed 1) an ubiquitin network involving the regulation of mammalian iron metabolism, 2) regulatory mechanisms of the Hippo intracellular pathway, and 3) a regulatory mechanism of host anti-cancer immunity by the tumor-intrinsic signaling pathway. The goal of our research is to understand cell-cell communication mechanisms regulating tissue homeostasis, and to provide scientific basis for drug discovery.

Iron metabolism

Work in our lab is currently focusing on describing a new regulatory network controlling iron metabolism.

Hippo pathway

A focus of our lab is to understand physiological regulations of and by the Hippo pathway in development and cancer.

Cancer immunity

We aim to understand how cancer cell immunogenicity is regulated by intracellular signaling network.

熊本大学 大学院生命科学研究部

総合医薬科学部門 代謝・循環医学分野



〒860-8556 熊本市中央区本荘1-1-1

(受付) TEL: 096-373-5173

FAX: 096-373-5313

E-MAIL: moroishi [at]

Department of Molecular and Medical Pharmacology

Faculty of Life Sciences, Kumamoto University


1-1-1 Honjo, Chuo-ku, Kumamoto,

Kumamoto 860-8556, JAPAN

(Desk) TEL: +81-96-373-5173

FAX: +81-96-373-5313
E-MAIL: moroishi [at]