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Horiguchi, H., Kadomatsu, T., Miyata, K., Terada, K., Sata, M., Torigoe, D., Morinaga, J., Moroishi, T., and Oike, Y.

Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis

Oncogene , in press (2020).

Shimoda, M., and Moroishi, T.

The Emerging Link between the Hippo Pathway and Non-coding RNA

Biol. Pharm. Bull. 43, 1-10 (2020). 

Horiguchi, H., Kadomatsu, T., Kurahashi, R., Hara, C., Miyata, K., Baba, M., Osumi, H., Terada, K., Araki, K., Takai, T., Kamba, T., Linehan, W.M., Moroishi, T., and Oike, Y.

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity

Genes Dev. 33, 1641-1656 (2019).

Shinchi, H., Yamaguchi, T, Moroishi, T., Yuki, M., Wakao, M., Hayashi, T., Cottam, H.B., Carson, D.A., and Suda, Y. 

Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants

Bioconjugate Chem. 30, 2811-2821 (2019).

Moroishi, T.

Spotlight on early-career researchers: an interview with Toshiro Moroishi

Commun. Biol. 2, 341 (2019). 

Yamauchi, T., and Moroishi, T.

Hippo Pathway in Mammalian Adaptive Immune System

Cells 8, 398 (2019). 

Verma, S., Yeddula, N., Soda, Y., Zhu, Q., Pao, G.M., Moresco, J., Diedrich, J.K., Hong, A., Plouffe, S., Moroishi, T., Guan, K.L., and Verma, I.M.

BRCA1/BARD1 dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling

Proc. Natl. Acad. Sci. U. S. A. 116, 7363-7370 (2019).

*Muto, Y., *Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y., and Nakayama, K.I.

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

J. Exp. Med. 216, 950-965 (2019). [*Equal contribution]

Mon, E.E., Wei, F.Y., Ahmad, R.N.R., Yamamoto, T., Moroishi, T., and Tomizawa, K.

Regulation of mitochondrial iron homeostasis by sideroflexin 2

J. Physiol. Sci. 69, 359-373 (2019).

Pan, W.W., Moroishi, T., Koo,J.H., and Guan, K.L.

Cell type-dependent function of LATS1/2 in cancer cell growth

Oncogene 38, 2595-2610 (2019).

Meng, Z., Qiu, Y., Lin, K.C., Kumar, A., Placone, J.K., Fang, C., Wang, K.C., Lu, S., Pan, M., Hong, A.W., Moroishi, T., Luo, M., Plouffe, S.W., Diao, Y., Ye, Z., Park, H.W., Wang, X., Yu, F.X., Chien, S., Wang, C.Y., Ren, B., Engler, A.J., and Guan, K.L.

RAP2 mediates mechanoresponses of Hippo pathway

Nature 560, 655-660 (2018). 

Martin, D., Degese, M.S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J.L.C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., Thorne, R.F., Zaida, M., Siegele, B., Cheong, S.C., Molinolo, A.A., Samuels, Y., Tamayo, P., Guan, K.L., Lippman, S.M., Lyons, J.G., and Gutkind, J.S.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

Nat. Commun. 9, 2372 (2018).

Cosset, E., Ilmjarv, S., Dutoit, V., Elliott, K., von Schalscha, T., Camargo, M. F., Reiss, A., Moroishi, T., Seguin, L., Gomez, G., Moo, J. S., Preynat-Seauve, O., Krause, K. H., Chneiweiss, H., Sarkaria, J. N., Guan, K. L., Dietrich, P. Y., Weis, S. M., Mischel, P. S., and Cheresh, D. A.

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma

Cancer Cell 32, 856-868 (2017).

Lin, K.C., Moroishi, T., Meng, Z., Jeong, H.S., Plouffe, S.W., Sekido, Y., Han, J., Park, H.W., and Guan, K.L.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation

Nat. Cell Biol. 19, 996-1002 (2017).

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T., and Nakayama, K.I.

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Nat. Commun. 8, 16114 (2017).

Taniguchi, K., Moroishi, T., de Jong, P.R., Krawczyk, M., Grebbin, B.M., Luo, H., Xu, R.H., Golob-Schwarzl, N., Schweiger, C., Wang, K., Di Caro, G., Feng, Y., Fearon, E.R., Raz, E., Kenner, L., Farin, H.F., Guan, K.L., Haybaeck, J., Datz, C., Zhang, K., and Karin, M.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis

Proc. Natl. Acad. Sci. U. S. A. 114, 1643-1648 (2017).

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A., and Nakayama, K.I.

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem-Progenitor Cells

Mol. Cell. Biol. 37, e00470-16 (2017).

Moroishi, T., Hayashi, T., Pan, W.W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K.L.

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

Cell 167, 1525-1539 (2016).

Fu, V., Moroishi, T., and Guan, K.L.

Glycoholics Anonymous: Cancer Sobers Up with mTORC1

Cancer Cell 29, 432-434 (2016).

Meng, Z., Moroishi, T., and Guan, K.L.

Mechanisms of Hippo pathway regulation

Genes Dev. 30, 1-17 (2016).

Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S.W., Hansen, C.G., Hong, A.W., Park, H.W., Mo, J.S., Lu, W., Lu, S., Flores, F., Yu, F.X., Halder, G., and Guan, K.L.

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

Nat. Commun. 6, 8357 (2015).

Park, H.W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J.S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., Wang, C.Y., and Guan, K.L.

Alternative Wnt Signaling Activates YAP/TAZ

Cell 162, 780-794 (2015).

Moroishi, T., Park, H.W., Qin, B., Chen, Q., Meng, Z., Plouffe, S.W., Taniguchi, K., Yu, F.X., Karin, M., Pan, D., and Guan, K.L.

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis

Genes Dev. 29, 1271-1284 (2015).

*Hansen, C.G., *Moroishi, T., and Guan, K.L.

YAP and TAZ: a nexus for Hippo signaling and beyond

Trends Cell Biol. 25, 499-513 (2015). [*Equal contribution]

*Moroishi, T., *Hansen, C.G., and Guan, K.L.

The emerging roles of YAP and TAZ in cancer

Nat. Rev. Cancer 15, 73-79 (2015). [*Equal contribution]

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K., and Nakayama, K.I.

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24

Mol. Cell. Biol. 34, 3321-3340 (2014).

Moroishi, T., Yamauchi, T., Nishiyama, M., and Nakayama, K.I.

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism

J. Biol. Chem. 289, 16430-16441 (2014).

Yumimoto, K., Matsumoto, M., Oyamada, K., Moroishi, T., and Nakayama, K.I.

Comprehensive identification of substrates for F-box proteins by differential proteomics analysis

J. Proteome Res. 11, 3175-3185 (2012).

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K., and Nakayama, K.I.

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Cell Metab. 14, 339-351 (2011).

熊本大学 大学院生命科学研究部

総合医薬科学部門 代謝・循環医学分野



〒860-8556 熊本市中央区本荘1-1-1

(受付) TEL: 096-373-5173

FAX: 096-373-5313

E-MAIL: moroishi [at]

Department of Cell Signaling and Metabolic Medicine

Faculty of Life Sciences, Kumamoto University


1-1-1 Honjo, Chuo-ku, Kumamoto,

Kumamoto 860-8556, JAPAN

(Desk) TEL: +81-96-373-5173

FAX: +81-96-373-5313
E-MAIL: moroishi [at]