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Hinokuma, H., Kanamori, Y., Ikeda, K., Hao, L., Maruno, M., Yamane, T., Maeda, A., Nita, A., Shimoda, M., Niimura, M., Takeshima, Y., Li, S., Suzuki, M., and Moroishi, T.

Distinct functions between ferrous and ferric iron in lung cancer cell growth.

Cancer Sci., in press (2023).


Yamane, T., Kanamori, Y., Sawayama, H., Yano, H., Nita, A., Ohta, Y., Hinokuma, H., Maeda, A., Iwai, A., Matsumoto, T., Shimoda, M., Niimura, M., Usuki, S., Yasuda-Yoshihara, N., Niwa, M., Baba, Y., Ishimoto, T., Komohara, Y., Sawa, T., Hirayama, T., Baba, H., and Moroishi, T.

Iron accelerates Fusobacterium nucleatum-induced CCL8 expression in macrophages and is associated with colorectal cancer progression.

JCI insight 7, e156802 (2022).

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Bu, L., Yonemura, A., Yasuda-Yoshihara, N., Uchihara, T., Ismagulov, G., Takasugi, S., Yasuda, T., Okamoto, Y., Kitamura, F., Akiyama, T., Arima, K., Itoyama, R., Zhang, J., Fu, L., Hu, X., Wei, F., Arima, Y., Moroishi, T., Nishiyama, K., Sheng, G., Mukunoki, T., Otani, J., Baba, H., and Ishimoto, T. 

Tumor microenvironmental 15-PGDH depletion promotes fibrotic tumor formation and angiogenesis in pancreatic cancer.

Cancer Sci. 113, 3579-3592 (2022).

Horiguchi, H., Kadomatsu, T., Yumoto, S., Masuda, T., Miyata, K., Yamamura, S., Sato, M., Morinaga, J., Ohtsuki, S., Baba, H., Moroishi, T., and Oike, Y.

Tumor cell-derived ANGPTL2 promotes β-catenin-driven intestinal tumorigenesis.

Oncogene 41, 4028-4041 (2022).

Shinchi, H., Komaki, F., Yuki, M., Ohara, H., Hayakawa, N., Wakao, M., Cottam, H.B., Hayashi, T., Carson, D.A., Moroishi, T., and Suda, Y. 

Glyco-Nanoadjuvants: Impact of Linker Length for Conjugating a Synthetic Small-Molecule TLR7 Ligand to Glyco-Nanoparticles on Immunostimulatory Effects.

ACS Chem. Biol. 17, 957-968 (2022).

Nomoto, D., Baba, Y., Liu, Y., Tsutsuki, H., Okadome, K., Harada, K., Ishimoto, T., Iwatsuki, M., Iwagami, S., Miyamoto, Y., Yoshida, N., Watanabe, M., Moroishi, T., Komohara, Y., Sawa, T., Baba, H. 

Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-kappaB pathway.

Cancer Lett. 530, 59-67 (2022).

Yu, L., Zhou, D., Zhang, G., Ren, Z., Luo, X., Liu, P., Plouffe, S.W., Meng, Z., Moroishi, T., Li, Y., Zhang, Y., Brown, J.H., Liu, S., and Guan, K.L.

Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.

Mol. Oncol. 16, 607-629 (2022).

Moroishi, T.

ANXious for YAP.

Nat. Chem. Biol. 17, 750–751 (2021). 


Shinchi, H., Yuki, M., Yamauchi, T., Niimura, M., Wakao M., Cottam, H.B., Hayashi, T., Carson, D.A., Moroishi, T., and Suda, Y. 

Glyco-Nanoadjuvants: Sugar Structures on Carriers of a Small Molecule TLR7 Ligand Affect Their Immunostimulatory Activities.

ACS Appl. Bio Mater. 4, 2732-2741 (2021).

Yamauchi, T., and Moroishi, T.

The Yin and Yang of tumor-derived extracellular vesicles in tumor immunity.

J. Biochem. 169, 155-161 (2021).


Horiguchi, H., Kadomatsu, T., Miyata, K., Terada, K., Sata, M., Torigoe, D., Morinaga, J., Moroishi, T., and Oike, Y.

Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis.

Oncogene 40, 55–67 (2021).

Luo, M., Meng, Z., Moroishi, T., Lin, K. C., Shen, G., Mo, F., Shao, B., Wei, X., Zhang, P., Wei, Y., and Guan, K.L. 

Heat stress activates YAP/TAZ to induce the heat shock transcriptome.

Nat. Cell Biol. 22, 1447–1459 (2020).

Shimoda, M., and Moroishi, T.

The Emerging Link between the Hippo Pathway and Non-coding RNA.

Biol. Pharm. Bull. 43, 1-10 (2020). 

Horiguchi, H., Kadomatsu, T., Kurahashi, R., Hara, C., Miyata, K., Baba, M., Osumi, H., Terada, K., Araki, K., Takai, T., Kamba, T., Linehan, W.M., Moroishi, T., and Oike, Y.

Dual functions of angiopoietin-like protein 2 signaling in tumor progression and anti-tumor immunity.

Genes Dev. 33, 1641-1656 (2019).

Shinchi, H., Yamaguchi, T, Moroishi, T., Yuki, M., Wakao, M., Hayashi, T., Cottam, H.B., Carson, D.A., and Suda, Y. 

Gold nanoparticles co-immobilized with small molecule toll-like receptor 7 ligand and α-mannose as adjuvants.

Bioconjugate Chem. 30, 2811-2821 (2019).

Moroishi, T.

Spotlight on early-career researchers: an interview with Toshiro Moroishi.

Commun. Biol. 2, 341 (2019). 

Yamauchi, T., and Moroishi, T.

Hippo pathway in mammalian adaptive immune system.

Cells 8, 398 (2019). 

Verma, S., Yeddula, N., Soda, Y., Zhu, Q., Pao, G.M., Moresco, J., Diedrich, J.K., Hong, A., Plouffe, S., Moroishi, T., Guan, K.L., and Verma, I.M.

BRCA1/BARD1 dependent ubiquitination of NF2 regulates Hippo-YAP1 signaling.

Proc. Natl. Acad. Sci. U. S. A. 116, 7363-7370 (2019).

*Muto, Y., *Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y., and Nakayama, K.I.

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.

J. Exp. Med. 216, 950-965 (2019). [*Equal contribution]

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Mon, E.E., Wei, F.Y., Ahmad, R.N.R., Yamamoto, T., Moroishi, T., and Tomizawa, K.

Regulation of mitochondrial iron homeostasis by sideroflexin 2.

J. Physiol. Sci. 69, 359-373 (2019).

Pan, W.W., Moroishi, T., Koo,J.H., and Guan, K.L.

Cell type-dependent function of LATS1/2 in cancer cell growth

Oncogene 38, 2595-2610 (2019).

Meng, Z., Qiu, Y., Lin, K.C., Kumar, A., Placone, J.K., Fang, C., Wang, K.C., Lu, S., Pan, M., Hong, A.W., Moroishi, T., Luo, M., Plouffe, S.W., Diao, Y., Ye, Z., Park, H.W., Wang, X., Yu, F.X., Chien, S., Wang, C.Y., Ren, B., Engler, A.J., and Guan, K.L.

RAP2 mediates mechanoresponses of Hippo pathway.

Nature 560, 655-660 (2018). 

Martin, D., Degese, M.S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J.L.C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., Thorne, R.F., Zaida, M., Siegele, B., Cheong, S.C., Molinolo, A.A., Samuels, Y., Tamayo, P., Guan, K.L., Lippman, S.M., Lyons, J.G., and Gutkind, J.S.

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor.

Nat. Commun. 9, 2372 (2018).

Cosset, E., Ilmjarv, S., Dutoit, V., Elliott, K., von Schalscha, T., Camargo, M. F., Reiss, A., Moroishi, T., Seguin, L., Gomez, G., Moo, J. S., Preynat-Seauve, O., Krause, K. H., Chneiweiss, H., Sarkaria, J. N., Guan, K. L., Dietrich, P. Y., Weis, S. M., Mischel, P. S., and Cheresh, D. A.

Glut3 Addiction Is a Druggable Vulnerability for a Molecularly Defined Subpopulation of Glioblastoma.

Cancer Cell 32, 856-868 (2017).

Lin, K.C., Moroishi, T., Meng, Z., Jeong, H.S., Plouffe, S.W., Sekido, Y., Han, J., Park, H.W., and Guan, K.L.

Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation.

Nat. Cell Biol. 19, 996-1002 (2017).

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T., and Nakayama, K.I.

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells.

Nat. Commun. 8, 16114 (2017).

Taniguchi, K., Moroishi, T., de Jong, P.R., Krawczyk, M., Grebbin, B.M., Luo, H., Xu, R.H., Golob-Schwarzl, N., Schweiger, C., Wang, K., Di Caro, G., Feng, Y., Fearon, E.R., Raz, E., Kenner, L., Farin, H.F., Guan, K.L., Haybaeck, J., Datz, C., Zhang, K., and Karin, M.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis.

Proc. Natl. Acad. Sci. U. S. A. 114, 1643-1648 (2017).

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A., and Nakayama, K.I.

FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem-Progenitor Cells.

Mol. Cell. Biol. 37, e00470-16 (2017).

Moroishi, T., Hayashi, T., Pan, W.W., Fujita, Y., Holt, M.V., Qin, J., Carson, D.A., and Guan, K.L.

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.

Cell 167, 1525-1539 (2016).

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Fu, V., Moroishi, T., and Guan, K.L.

Glycoholics Anonymous: Cancer Sobers Up with mTORC1.

Cancer Cell 29, 432-434 (2016).

Meng, Z., Moroishi, T., and Guan, K.L.

Mechanisms of Hippo pathway regulation.

Genes Dev. 30, 1-17 (2016).

Meng, Z., Moroishi, T., Mottier-Pavie, V., Plouffe, S.W., Hansen, C.G., Hong, A.W., Park, H.W., Mo, J.S., Lu, W., Lu, S., Flores, F., Yu, F.X., Halder, G., and Guan, K.L.

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway.

Nat. Commun. 6, 8357 (2015).

Park, H.W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J.S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., Wang, C.Y., and Guan, K.L.

Alternative Wnt Signaling Activates YAP/TAZ.

Cell 162, 780-794 (2015).

Moroishi, T., Park, H.W., Qin, B., Chen, Q., Meng, Z., Plouffe, S.W., Taniguchi, K., Yu, F.X., Karin, M., Pan, D., and Guan, K.L.

A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis.

Genes Dev. 29, 1271-1284 (2015).

*Hansen, C.G., *Moroishi, T., and Guan, K.L.

YAP and TAZ: a nexus for Hippo signaling and beyond.

Trends Cell Biol. 25, 499-513 (2015). [*Equal contribution]


*Moroishi, T., *Hansen, C.G., and Guan, K.L.

The emerging roles of YAP and TAZ in cancer.

Nat. Rev. Cancer 15, 73-79 (2015). [*Equal contribution]

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K., and Nakayama, K.I.

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24.

Mol. Cell. Biol. 34, 3321-3340 (2014).

Moroishi, T., Yamauchi, T., Nishiyama, M., and Nakayama, K.I.

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.

J. Biol. Chem. 289, 16430-16441 (2014).

Yumimoto, K., Matsumoto, M., Oyamada, K., Moroishi, T., and Nakayama, K.I.

Comprehensive identification of substrates for F-box proteins by differential proteomics analysis.

J. Proteome Res. 11, 3175-3185 (2012).

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K., and Nakayama, K.I.

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.

Cell Metab. 14, 339-351 (2011).

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熊本大学 大学院生命科学研究部

総合医薬科学部門 代謝・循環医学分野



〒860-8556 熊本市中央区本荘1-1-1

(受付) TEL: 096-373-5173

FAX: 096-373-5313

E-MAIL: moroishi [at]

Department of Molecular and Medical Pharmacology

Faculty of Life Sciences, Kumamoto University


1-1-1 Honjo, Chuo-ku, Kumamoto,

Kumamoto 860-8556, JAPAN

(Desk) TEL: +81-96-373-5173

FAX: +81-96-373-5313
E-MAIL: moroishi [at]